Immunological reminiscence is a trademark of adaptive immunity and facilitates an sped up and enhanced immune reaction upon re-infection with the similar pathogen1,2. Because the outbreak of the continuing coronavirus illness 19 (COVID-19) pandemic, a key query has involved in which serious acute respiration syndrome coronavirus 2 (SARS-CoV-2)-specific T cells stimulated right through acute an infection give upward push to long-lived reminiscence T cells3. The use of spectral float cytometry mixed with cell indexing of transcriptomes and T cellular receptor (TCR) sequencing we longitudinally represent particular person SARS-CoV-2-specific CD8+ T cells of COVID-19 sufferers from acute an infection to 1 12 months into restoration and discover a distinct signature figuring out long-lived reminiscence CD8+ T cells. SARS-CoV-2-specific reminiscence CD8+ T cells persisting three hundred and sixty five days after acute an infection categorical CD45RA, interleukin-7 receptor α (CD127), and T cellular factor-1 (TCF1), however they care for low CCR7, thus equivalent to CD45RA+ effector-memory T (TEMRA) cells. Monitoring particular person clones of SARS-CoV-2-specific CD8+ T cells, we divulge that an interferon signature marks clones giving upward push to long-lived cells, while extended proliferation and mammalian goal of rapamycin (mTOR) signaling are related to clonal disappearance from the blood. Jointly, we describe a transcriptional signature that marks long-lived, circulating human reminiscence CD8+ T cells following an acute virus an infection.